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TGN1412
TGN1412 (merknaam CD28-SuperMAB®) is een immunomodulatorisch geneesmiddel. Het is een monoklonaal antilichaam dat een superagonistische werking heeft op CD28.
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1. TGN1412 was known to activate CD28 strongly, the scientists said.
2. Dr Thomas Hanke said healthy participants were used because the compound, TGN1412, was not thought toxic.
3. Almost all monoclonal antibody drugs aim to suppress an immune system reaction, but TGN1412 does the opposite.
4. More polls» They were testing TGN1412, a drug that was hoped would treat rheumatoid arthritis, leukaemia and multiple sclerosis.
5. Thomas Hanke, TeGenero‘s chief scientific officer, said Wednesday that TGN1412 had not caused any problems in previous testing.